The goal of this course is a systematic study of modern instrumental methods of chemical analysis with emphasis on the principles of operation of the instruments and their use for the analysis of real substances. Topics and learning goals include, but are not limited to, atomic and molecular spectroscopy, gas and liquid chromatography, mass spectrometry. Laboratory skills and learning goals include extensive hands-on experience with major analytical instrumentation: UV-Vis absorption, AAS, ICP-AES, GC and HPLC as well as important instrumentation construction skills such as data acquisition and control, electronics and the use of the machine shop. Emphasizes study of complex mixtures and the special problems of trace-level analysis. Learning outcomes include the successful understanding of the indicated goals.